Sequence:

MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS

Molecular weight:

Monomer, 12.9 kDa (115 aa)

Recipe:

CTGrade GMP rhIL-15 was freeze-dried at 1 mg/ml in 10 mM sodium bicarbonate (pH 8.0, 0.2 μm)

Protein purity:

≥ 97% determined by reduced and non reduced SDS-PAGE analysis

Endotoxins:

< 0.05 EU/μg

Biological activity:

ED50 is determined by dose-dependent proliferation of CTLL-2 cells. ED50 is usually less than 1 ng/mL.

English description:

IL-15 is a widely expressed proinflammatory cytokine that is structurally and functionally related to IL-2.
Signals through JAK kinases to activate STAT3, STAT5, and STAT6 transcription factors
Regulates the activation of T cells, neutrophils, and macrophages, and is a stimulatory cytokine promoting dendritic cell function
Dysregulated in chronic inflammatory disorders, including rheumatoid arthritis, psoriasis, and pulmonary inflammatory diseases