Sequence:

MLGQDMVSPE ATNSSSSSFS SPSSAGRHVR SYNHLQGDVR WRKLFSFTKY FLKIEKNGKV SGTKKENCPY SILEITSVEIGVVAVKAINS NYYLAMNKKG KLYGSKEFNN DCKLKERIEE NGYNTYASFN WQHNGRQMYV ALNGKGAPRR GQKTRRKNTS AHFLPMVVHS

Molecular weight:

Monomer, 19.3 kDa (170 aa)

Recipe:

Freeze dry from a 0.2 μ m filtered solution containing 10 mM sodium phosphate (pH 7.5)

Protein purity:

≥ 95% determined by reduced and non reduced SDS-PAGE analysis

Endotoxins:

≤ 0.1 EU/μg

Biological activity:

ED50 proliferation of 4MBr-5 cells ≤ 200 ng/mL

English description:

Fibroblast growth factor 10 (FGF-10) is a growth factor that is important during embryonic development, especially during lung, limb, brain, heart, and kidney morphogenesis. FGF-10 is expressed in mesenchymal cells and facilitates epithelial-mesenchymal signaling through binding the epithelially expressed FGF receptor 2b (FGFR2b). FGF-10 also functions as a mitogen for keratinizing epidermal cells, and induces the migration and invasion of cancer cells.