Sequence:

MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS

Molecular weight:

Monomer, 15.4 kDa (132 aa)

Recipe:

CTGrade rhIL-21 was freeze-dried at 1 mg/ml in 10 mM sodium phosphate (pH 7.5, 0.2 μ m) and filtered

Protein purity:

≥ 97% determined by reduced and non reduced SDS-PAGE analysis

Endotoxins:

< 0.05 EU/μg

Biological activity:

ED50 is determined by dose-dependent proliferation of B9 cells. ED50 is usually less than 5 ng/mL.

English description:

IL-21 is a common chain cytokine regulating many cell types of the immune system. The IL-21 receptor (IL-21R) activates the JAK/STAT signaling pathway and is expressed on T, B, and natural killer (NK) cells.