Sequence:

MPGPPPGPPR VSPDPRAELD STVLLTRSLL ADTRQLAAQL RDKFPADGDH NLDSLPTLAM SAGALGALQL PGVLTRLRAD LLSYLRHVQW LRRAGGSSLK TLEPELGTLQ ARLDRLLRRL QLLMSRLALP QPPPDPPAPP LAPPSSAWGG IRAAHAILGG LHLTLDWAVR GLLLLKTRL

Molecular weight:

Monomer, 19.3 kDa (179 aa)

Recipe:

Freeze dry from a 0.2 μ m filtered solution containing 0.1% trifluoroacetic acid (TFA)

Protein purity:

≥ 95% determined by reduced and non reduced SDS-PAGE analysis

Endotoxins:

≤ 0.1 EU/μg

Biological activity:

ED50 proliferation of TF-1 cells ≤ 10 ng/mL

English description:

Interleukin 11 (IL-11) is a member of the gp130 family of cytokines. IL-11 functions to promote hematopoietic stem cell proliferation and megakaryocyte differentiation. In non-hematopoietic cell populations, IL-11 stimulates acute-phase proteins, modulates the development of immunoglobulin-producing B cells, and regulates bone turnover. IL-11 binds the IL-11Rα receptor to activate JAK downstream signaling.